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  1. Ilott I, Rick J, Patterson M, Turgoose C, Lacey A. What is protocol-based care? A concept analysis. J Nurs Manag. 2006;14(7):544-52. doi: 10.1111/j.1365-2934.2006.00703.

  2. Gulwani S. Programming by examples: Applications, algorithms, and ambiguity resolution.Redmond, WA: Microsoft Corporation; 2016.

  3. Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287.

  4. Jun GT, Ward J, Morris Z, Clarkson J. Health care process modelling: which method when?. Int J Qual Health Care. 2009;21(3):214- 224.    doi: 10.1093/intqhc/mzp016.

  5. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mul-row CD, et al. The PRISMA 2020 statement: an updated guide-line for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71.

  6. Savage RD, Fowler RA, Rishu AH, Bagshaw SM, Cook D, Dodek P, et al. Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study. CMAJ Open. 2016;4(4):E569-E577. doi: 10.9778/cmajo.20160074.

  7. Bone RC. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med. 1996;125(8):680-687. doi: 10.7326/0003-4819-125-8-199610150-00009.

  8. Vincent JL, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet. 22013;381(9868):774-5. doi: 10.1016/S0140-6736(12)61815-7.

  9. Van der Poll T, Lowry SF. Tumor necrosis factor in sepsis: mediator of multiple organ failure or essential part of host defense?Shock (Augusta, Ga). 1995;3(1):1-12. doi: 10.1097/00024382-199501000-00001.

  10. Pruitt JH, Copeland EM, Moldawer LL. Interleukin-1 and interleu-kin-1 antagonism in sepsis, systemic inflammatory response syndrome, and septic shock. Shock (Augusta, Ga). 1995;3(4):235-51. doi: 10.1097/00024382-199504000-00001.

  11. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546-1554. doi: 10.1056/NEJMoa022139.

  12. Walkey AJ, Wiener RS, Lindenauer PK. Utilization patterns and outcomes associated with central venous catheter in septic shock: a population-based study. Crit Care Med. 2013;41(6):1450-1457. doi: 10.1097/CCM.0b013e31827caa89.

  13. Ortíz G, Dueñas C, Rodríguez F, et al. Epidemiology of sepsis in Colombian intensive care units. Biomedica. 2014;34(1):40-47. doi: 10.1590/S0120-4157201400010000.

  14. Borges M, Candel F, Ferrer R, Vidal P, Zaragoza R. Código Sepsis. Documento de Consenso. 2014;5-60. https://seguridaddelpa-ciente.es/resources/documentos/2016/SEPSIS-DOCUMEN-TO-DE-CONSENSO.pdf

  15. Brouwers MC, Kerkvliet K, Spithoff K; AGREE Next Steps Consortium. The AGREE Reporting Checklist: a tool to improve re-porting of clinical practice guidelines. BMJ. 2016; i1152. doi: 10.1136/bmj.i1152.

  16. National Institute for Health and Care Excellence (NICE) Guidance. Sepsis: recognition, diagnosis and early management: © NICE (2017) Sepsis: recognition, diagnosis and early management. BJU Int. 2018;121(4):497-514. doi: 10.1111/bju.14179.

  17. Nishida O, Ogura H, Egi M, Fujishima S, Hayashi Y, Iba T, et al. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). J Intensive Care. 2018;6(1):7. doi: 10.1186/s40560-017-0270-8.

  18. García Palomo JD, Agüero Balbín J, Parra Blanco JA, Santos Benito MF. Enfermedades infecciosas. Concepto. Clasificación. Aspectos generales y específicos de las infecciones. Criterios de sospecha de enfermedad infecciosa. Pruebas diagnósticas complementarias. Criterios de indicación. Medicine (Madr). 2010;10(49):3251-3264. doi: 10.1016/S0304-5412(10)70027-5.

  19.  Acosta-Gnass SI. Manual de Control de infecciones y epidemiología hospitalaria. Washington D.C.: Organización Panamericana de la Salud; 2011.

  20. Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013;50(1):23- 36.    doi: 10.3109/10408363.2013.764490.

  21. Ginn AN, Halliday CL, Douglas AP, Chen SC. PCR-based tests for the early diagnosis of sepsis. Where do we stand?. Curr Opin Infect Dis. 2017;30(6):565-572. doi: 10.1097/QCO.0000000000000407.

  22.  England. Royal College of Physicians. [Internet]. London: Royal College of Physicians [cited 2022 Apr 9]. National Early Warning Score (NEWS) 2. Available from:  https://www.rcplondon.ac.uk/projects/outputs/national-early-warning-score-news-2.

  23. Williams B. The National Early Warning Score and the acutely con-fused patient. Clin Med (Lond). 2019 Mar;19(2):190-191. doi: 10.7861/clinmedicine.19-2-190.

  24. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving Sepsis Campaign: International Guide-lines for Management of Sepsis and Septic Shock 2021. Intensive Care Med.2021;47(11):1181-1247. doi: 10.1007/s00134- 021-    06506-y.

  25. Ferreira FL, Bota DP, Bross A, Mélot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286(14):1754-1758. doi: 10.1001/jama.286.14.1754.

  26. Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third Internation-al Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):775-787. doi: 10.1001/jama.2016.0289.

  27.  Morgan TJ. The ideal crystalloid - what is «balanced»? Curr Opin Crit Care. 2013;19(4):299-307. doi:10.1097/MCC. 0b013e3283632d46.

  28. Gheorghe C, Dadu R, Blot C, Barrantes F, Vazquez R, Berianu F, et al. Hyperchloremic metabolic acidosis following resuscitation of shock. 2010;138(6):1521-1522. doi: 10.1378/chest.10-1458.

  29. Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults. JAMA. 2012;308(15):1566-72. doi:10.1001/jama.2012.13356.

  30. Finfer S, Myburgh J, Bellomo R. Intravenous fluid therapy in criti-cally ill adults. [published correction appears in Nat Rev Nephrol. 2018 Nov;14(11):717]. Nat Rev Nephrol. 2018;14(9):541-557. doi: 10.1038/s41581-018-0044-0. 

  31. Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014;370(15):1412-1421. doi: 10.1056/NEJMoa1305727.

  32. Xu JY, Chen QH, Xie JF, Pan C, Liu SQ, Huang LW, et al. Comparison of the effects of albumin and crystalloid on mortality in adult patients with severe sepsis and septic shock: a meta-anal-ysis of randomized clinical trials. Crit Care. 2014;18(6):702. doi: 10.1186/s13054-014-0702-y.

  33. Jiang L, Jiang S, Zhang M, Zheng Z, Ma Y. Albumin versus other flu-ids for fluid resuscitation in patients with sepsis: a meta-analysis. PLoS One. 2014;9(12):e114666. Published 2014 Dec 4. doi: 10.1371/journal.pone.0114666.

  34. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350(22):2247-2256. doi: 10.1056/NEJMoa040232.

  35. Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, et al. Hydroxyethyl Starch 130/0.42 versus Ringer’s Acetate in Severe Sepsis. New England Journal of Medicine. 12 de julio de 2012;367(2):124-34.

  36. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis [published correction appears in N Engl J Med. 2012 Aug 2;367(5):481]. N Engl J Med. 2012;367(2):124- 134.    doi: 10.1056/NEJMoa1204242.

  37. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. 2012. In-tensive Care Med. 2013;39(2):165-228. doi: 10.1007/s00134- 012-    2769-8.

  38. Cherpanath TG V., Hirsch A, Geerts BF, Lagrand WK, Leeflang MM, Schultz MJ, et al. Predicting Fluid Responsiveness by Pas-sive Leg Raising: A Systematic Review and Meta-Analysis of 23 Clinical Trials. Crit Care Med. 2016;44(5):981-991. doi: 10.1097/CCM.0000000000001556.

  39. Bentzer P, Griesdale DE, Boyd J, MacLean K, Sirounis D, Ayas NT. Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids? JAMA. 2016;316(12):1298-1309. doi: 10.1001/jama.2016.12310. 

  40. Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE. The Impact of Timing of Antibiotics on Outcomes in Severe Sep-sis and Septic Shock: A Systematic Review and Meta-analy-sis. Crit Care Med. 2015;43(9):1907-1915. doi: 10.1097/ CCM.    0000000000001142.

  41. Johnson MT, Reichley R, Hoppe-Bauer J, Dunne WM, Micek S, Kollef M. Impact of previous antibiotic therapy on outcome of Gram-negative severe sepsis. Crit Care Med. 2011;39(8):1859-1865. doi: 10.1097/CCM.0b013e31821b85f4.

  42. Weiss CH, Moazed F, McEvoy CA, Singer BD, Szleifer I, Amaral LAN, et al. Prompting physicians to address a daily checklist and process of care and clinical outcomes: a single-site study. Am J Respir Crit Care Med. 2011;184(6):680-686. doi: 10.1164/rccm.201101-0037OC.

  43. Tabah A, Bassetti M, Kollef MH, Zahar JR, Paiva JA, Timsit JF, et al. Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP). Intensive Care Med. 2020;46(2):245-265. doi: 10.1007/s00134-019-05866-w.

  44. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society [published correction appears in Clin Infect Dis. 2017 May 1;64(9):1298] [published correction appears in Clin Infect Dis. 2017 Oct 15;65(8):1435] [published correction appears in Clin Infect Dis. 2017 Nov 29;65(12):2161]. Clin Infect Dis. 2016;63(5):e61-e111. doi: 10.1093/cid/ciw353.

  45. Pugh R, Grant C, Cooke RPD, Dempsey G. Short-course ver-sus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults. Cochrane Database Syst Rev. 2015;2015(8):CD007577. doi: 10.1002/14651858. CD007577.pub3.

  46.  Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Os-trosky-Zeichner L, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1-e50. doi: 10.1093/cid/civ933. 

  47.  Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis. 2011;52(4):e56-e93. doi: 10.1093/cid/cir073.

  48.  Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM, Ry-bak MJ, et al. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. [published correction appears in Circulation. 2015 Oct 27;132(17):e215] [published correction appears in Circulation. 2016 Aug 23;134(8):e113] [published correction appears in Circulation. 2018 Jul 31;138(5):e78-e79]. Circulation. 2015;132(15):1435-1486. doi: 10.1161/CIR.0000000000000296.

  49. Eliakim-Raz N, Yahav D, Paul M, Leibovici L. Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2013;68(10):2183-2191. doi: 10.1093/jac/dkt177.

  50. Hepburn MJ, Dooley DP, Skidmore PJ, Ellis MW, Starnes WF, Hasewinkle WC. Comparison of short-course (5 days) and standard (10 days) treatment for uncomplicated cellulitis. Arch Intern Med. 2004;164(15):1669-1674. doi: 10.1001/archinte.164.15.1669.

  51. Rattan R, Allen CJ, Sawyer RG, Askari R, Banton KL, Claridge JA, et al. Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy. J Am Coll Surg. 2016;222(4):440-6. doi: 10.1016/j.jamcollsurg.2015.12.050.

  52. Mohr NM, Wessman BT, Bassin B, Elie-Turenne MC, Ellender T, Emlet LL, et al. Boarding of Critically Ill Patients in the Emergency Department. Crit Care Med. 2020;48(8):1180-1187. doi: 10.1097/CCM.0000000000004385.

  53. Luce JM. Pathogenesis and management of septic shock. Chest. 1987;91(6):883-888. doi: 10.1378/chest.91.6.883.

  54. Ghosh S, Latimer RD, Gray BM, Harwood RJ, Oduro A. Endotoxin-induced organ injury. Crit Care Med. 1993;21(2 Sup-pl):S19-S24. doi: 10.1097/00003246-199302001-00005.

  55. Ochagavía A, Baigorri F, Mesquida J, Ayuela JM, Ferrániz A, García X, et al. Monitorización hemodinámica en el paciente crítico. Recomendaciones del Grupo de Trabajo de Cuidados Intensivos Cardiológicos y RCP de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias. Med Intensiva. 2014;38(3):154-169. doi: 10.1016/j.medin.2013.10.006.

  56. Hernández G, Ospina-Tascón GA, Damiani LP, Estenssoro E, Dubin A, Hurtado J, et al. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Lev-els on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial. JAMA. 2019;321(7):654-664. doi:10.1001/jama.2019.0071.

  57.  Weigl W, Adamski J, Onichimowski D, Nowakowski P, Wagner B. Methods of assessing fluid responsiveness in septic shock patients: a narrative review. Anaesthesiol Intensive Ther. 2022;54(2):175- 83.    doi: 10.5114/ait.2022.115368.

  58. Nates JL, Nunnally M, Kleinpell R, Blosser S, Goldner J, Birriel B, et al. ICU Admission, Discharge, and Triage Guidelines: A Frame-work to Enhance Clinical Operations, Development of Institutional Policies, and Further Research. Crit Care Med. 2016;44(8):1553-1602. doi: 10.1097/CCM.0000000000001856